Distributed Environment for Efficient Virtual Machine Image Management in Federated Cloud Architectures

The use of Virtual Machines (VM) in Cloud computing provides various benefits in the overall software engineering lifecycle. These include efficient elasticity mechanisms resulting in higher resource utilization and lower operational costs. VM as software artifacts are created using provider-specific templates, called VM images (VMI), and are stored in proprietary or public repositories for further use. However, some technology specific choices can limit the interoperability among various Cloud providers and bundle the VMIs with nonessential or redundant software packages, leading to increased storage size, prolonged VMI delivery, stagnant VMI instantiation and ultimately vendor lock-in. To address these challenges, we present a set of novel functionalities and design approaches for efficient operation of distributed VMI repositories, specifically tailored for enabling: (i) simplified creation of lightweight and size optimized VMIs tuned for specific application requirements; (ii) multi-objective VMI repository optimization; and (iii) efficient reasoning mechanism to help optimizing complex VMI operations. The evaluation results confirm that the presented approaches can enable VMI size reduction by up to 55%, while trimming the image creation time by 66%. Furthermore, the repository optimization algorithms, can reduce the VMI delivery time by up to 51% and cut down the storage expenses by 3%. Moreover, by implementing replication strategies, the optimization algorithms can increase the system reliability by 74%

ENTICE VM image analysis and optimised fragmentation

Virtual machine (VM) images (VMIs) often share common parts of significant size as they are stored individually. Using existing de-duplication techniques for such images are non-trivial, impose serious technical challenges, and requires direct access to clouds' proprietary image storages, which is not always feasible. We propose an alternative approach to split images into shared parts, called fragments, which are stored only once. Our solution requires a reasonably small set of base images available in the cloud, and additionally only the increments will be stored without the contents of base images, providing significant storage space savings. Composite images consisting of a base image and one or more fragments are assembled on- demand at VM deployment. Our technique can be used in conjunction with practically any popular cloud solution, and the storage of fragments is independent of the proprietary image storage of the cloud provider

Monitoring the early signs of cognitive decline in elderly by computer games: an MRI study

BACKGROUND: It is anticipated that current and future preventive therapies will likely be more effective in the early stages of dementia, when everyday functioning is not affected. Accordingly the early identification of people at risk is particularly important. In most cases, when subjects visit an expert and are examined using neuropsychological tests, the disease has already been developed. Contrary to this cognitive games are played by healthy, well functioning elderly people, subjects who should be monitored for early signs. Further advantages of cognitive games are their accessibility and their cost-effectiveness. PURPOSE: The aim of the investigation was to show that computer games can help to identify those who are at risk. In order to validate games analysis was completed which measured the correlations between results of the 'Find the Pairs' memory game and the volumes of the temporal brain regions previously found to be good predictors of later cognitive decline. PARTICIPANTS AND METHODS: 34 healthy elderly subjects were enrolled in the study. The volume of the cerebral structures was measured by MRI. Cortical reconstruction and volumetric segmentation were performed by Freesurfer. RESULTS: There was a correlation between the number of attempts and the time required to complete the memory game and the volume of the entorhinal cortex, the temporal pole, and the hippocampus. There was also a correlation between the results of the Paired Associates Learning (PAL) test and the memory game. CONCLUSIONS: The results gathered support the initial hypothesis that healthy elderly subjects achieving lower scores in the memory game have increased level of atrophy in the temporal brain structures and showed a decreased performance in the PAL test. Based on these results it can be concluded that memory games may be useful in early screening for cognitive decline

A novel tool to analyze MRI recurrence patterns in glioblastoma

At least 10% of glioblastoma relapses occur at distant and even contralateral locations. This disseminated growth limits surgical intervention and contributes to neurological morbidity. Preclinical data pointed toward a role for temozolomide (TMZ) in reducing radiotherapy-induced glioma cell invasiveness. Our objective was to develop and validate a new analysis tool of MRI data to examine the clinical recurrence pattern of glioblastomas. MRIcro software was used to map the location and extent of initial preoperative and recurrent tumors on MRI of 63 patients in the European Organisation for Research and Treatment of Cancer (EORTC) 26981/22981/National Cancer Institute of Canada (NCIC) CE.3 study into the same stereotaxic space. This allowed us to examine changes of site and distance between the initial and the recurrent tumor on the group level. Thirty of the 63 patients were treated using radiotherapy, while the other patients completed a radiotherapy-plus-TMZ treatment. Baseline characteristics (median age, KPS) and outcome data (progression-free survival, overall survival) of the patients included in this analysis resemble those of the general study cohort. The patient groups did not differ in the promoter methylation status of methyl guanine methyltransferase (MGMT). Overall frequency of distant recurrences was 20%. Analysis of recurrence patterns revealed no difference between the groups in the size of the recurrent tumor or in the differential effect on the distance of the recurrences from the preoperative tumor location. The data show the feasibility of groupwise recurrence pattern analysis. An effect of TMZ treatment on the recurrence pattern in the EORTC 26981/22981/NCIC CE.3 study could not be demonstrated. Neuro-Oncology 10, 1019-1024, 2008 (Posted to Neuro-Oncology [serial online], Doc. D08-00051, August 4, 2008. URL http://neuro-oncology.dukejournals.org; DOI: 10.1215/15228517-2008-058